2.1.8 Randomisation - Revision history

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‎C. Resources

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Anton.bespalov: /* B. Guidance & Expectations */

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Anton.bespalov: /* A. Background & Definitions */

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‎A. Background & Definitions

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‎A. Background & Definitions

@@ Line 44: / Line 44: @@
 Online tools to support randomisation:
-* [www.eda.nc3rs.org.uk NC3Rs’ Experimental Design Assistant]
+* [https://www.eda.nc3rs.org.uk NC3Rs’ Experimental Design Assistant]
-* QuickCalcs - [www.graphpad.com/quickcalcs/randMenu/]
+* [https://www.graphpad.com/quickcalcs/randMenu/ QuickCalcs]
-* Sealed Envelope - [https://www.sealedenvelope.com/simple-randomiser/v1/lists]
+* [https://www.sealedenvelope.com/simple-randomiser/v1/lists Sealed Envelope]
 * RandoMice software - [[https://doi.org/10.1371/journal.pone.0237096 read]] - [[https://github.com/Rve54/RandoMice/releases/ download and install]]
@@ Line 55: / Line 55: @@
 Reading material:
-Handbook of Experimental pharmacology chapter on randomization and blinding [https://link.springer.com/chapter/10.1007/164_2019_279]
+* [https://link.springer.com/chapter/10.1007/164_2019_279 Handbook of Experimental pharmacology chapter on randomization and blinding]

@@ Line 44: / Line 44: @@
 Online tools to support randomisation:
-* NC3Rs’ Experimental Design Assistant - [www.eda.nc3rs.org.uk]
+* [www.eda.nc3rs.org.uk NC3Rs’ Experimental Design Assistant]
 * QuickCalcs - [www.graphpad.com/quickcalcs/randMenu/]

← Older revision		Revision as of 16:44, 11 January 2021
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	* To consider adding this subject to a training program for new employees or refresher training (if appropriate)		* To consider adding this subject to a training program for new employees or refresher training (if appropriate)
		+	* To assess the risks of cross-contamination when animals housed in the same cage are exposed to different pharmacological treatments
	* To check whether there are feedback channels installed so that your colleagues can identify, record and report errors and critical incidents related to this subject (if appropriate)		* To check whether there are feedback channels installed so that your colleagues can identify, record and report errors and critical incidents related to this subject (if appropriate)

@@ Line 31: / Line 31: @@
 '''PLEASE DO NOT FORGET'''
 * To consider adding this subject to a training program for new employees or refresher training (if appropriate)
 * To check whether there are feedback channels installed so that your colleagues can identify, record and report errors and critical incidents related to this subject (if appropriate)

@@ Line 27: / Line 27: @@
 * Is pseudo-randomisation used instead of strongly recommended true randomisation?
 * Is there a risk that randomisation is introduced at allocation of subjects per experimental groups but is not maintained throughout the study conduct, outcome assessment and data analysis?
 '''PLEASE DO NOT FORGET'''
 * To consider adding this subject to a training program for new employees or refresher training (if appropriate)
 * To check whether there are feedback channels installed so that your colleagues can identify, record and report errors and critical incidents related to this subject (if appropriate)

@@ Line 3: / Line 3: @@
 Randomisation is a process of random assignment of experimental units to treatment conditions:
-* occurrence of one event should have no influence on the next event (independence principle)
+* occurrence of one event should have no influence on the next event (independence principle);
-randomisation sequence cannot be based on an easily memorizable and reproducible sequence (randomness principle)
+* randomisation sequence cannot be based on an easily memorizable and reproducible sequence (randomness principle).
 Randomization serves three main purposes:
-* enables the application of statistical tests based on the central limit theorem
+* enables the application of statistical tests based on the central limit theorem;
-prevents a potential impact of the selection bias due to differing baseline or confounding characteristics of the subjects
+* prevents a potential impact of the selection bias due to differing baseline or confounding characteristics of the subjects;
-supports the implementation of other means to reduce the risks of bias (such as blinding)
+* supports the implementation of other means to reduce the risks of bias (such as blinding).
 == B. Guidance & Expectations ==

2.1.8 Randomisation - Revision history

134.3.120.2: /* C. Resources */

134.3.120.2: /* C. Resources */

85.216.81.116: /* B. Guidance & Expectations​ */

Anton.bespalov: /* B. Guidance & Expectations​ */

Anton.bespalov: /* B. Guidance & Expectations​ */

Anton.bespalov: /* B. Guidance & Expectations​ */

Anton.bespalov: /* ​​​​​​​​​​​​​​​​​​​​​​​A. Background & Definitions */

Anton.bespalov: /* ​​​​​​​​​​​​​​​​​​​​​​​A. Background & Definitions */

Anton.bespalov: /* B. Guidance & Expectations​ */

Anton.bespalov: /* ​​​​​​​​​​​​​​​​​​​​​​​A. Background & Definitions */

85.216.81.116: /* B. Guidance & Expectations */

Anton.bespalov: /* B. Guidance & Expectations */

Anton.bespalov: /* B. Guidance & Expectations */

Anton.bespalov: /* B. Guidance & Expectations */

Anton.bespalov: /* A. Background & Definitions */

Anton.bespalov: /* A. Background & Definitions */

Anton.bespalov: /* B. Guidance & Expectations */

Anton.bespalov: /* A. Background & Definitions */