https://wiki.go-eqipd.org/index.php?action=history&feed=atom&title=3.4.1.7_Frequency_and_procedure_of_observation_of_animals 2026-06-25T13:11:55Z Revision history for this page on the wiki MediaWiki 1.31.0 https://wiki.go-eqipd.org/index.php?title=3.4.1.7_Frequency_and_procedure_of_observation_of_animals&diff=426&oldid=prev 2020-09-05T18:35:54Z

<p></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 18:35, 5 September 2020</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l18" >Line 18:</td> <td colspan="2" class="diff-lineno">Line 18:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== C. Resources ==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== C. Resources ==</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Template to describe information related to animal care and use (all items covered by Section 3.4.1) - 3.4.1 Animal care and use.<del class="diffchange diffchange-inline">docx​</del></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Template to describe information related to animal care and use (all items covered by Section 3.4.1) - <ins class="diffchange diffchange-inline">[https://paasp.sharepoint.com/:w:/s/EQIPD/ET18tqgUVfJCsYNYxexlgA8BnwRLEn0k8JcFmeQlTiQMoA?e=zoXuUf </ins>3.4.1 Animal care and use.<ins class="diffchange diffchange-inline">docx]​</ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>ARRIVE guidelines 2019 for reporting animal research <del class="diffchange diffchange-inline">- </del>[[ARRIVE 2.0]]​​</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>ARRIVE guidelines 2019 for reporting animal research &#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">* </ins>[[ARRIVE 2.0]]​​</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Online and other available guidance:</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Online and other available guidance:</div></td></tr> <!-- diff cache key dbs14739182:diff::1.12:old-175:rev-426 --> </table>

Bjoerngerlach https://wiki.go-eqipd.org/index.php?title=3.4.1.7_Frequency_and_procedure_of_observation_of_animals&diff=175&oldid=prev 2020-09-03T09:26:32Z

<p>Created page with &quot;== ​​​​​​​A. Background &amp; Definitions == According to modern legislation (e.g. Directive 2010/63/EU; Guide for the Care and Use of Laboratory Animals; NRC 2011),...&quot;</p> <p><b>New page</b></p><div>== ​​​​​​​A. Background &amp; Definitions ==<br /> According to modern legislation (e.g. Directive 2010/63/EU; Guide for the Care and Use of Laboratory Animals; NRC 2011), research animals are expected to be observed daily for signs of illness, injury, or abnormal behavior. The observation should be performed by personnel capable of recognize these signs, and a method to communicate any issue to the veterinarian implemented. In the presence of a critical situation, communication between veterinarian and Principal Investigator (PI) is essential. Nowadays, the authority of the veterinarian to take relieving measures (treatment, or even euthanasia) is recognized internationally. One of the main interpretation points is the implementation of humane endpoints, which are the earliest indicator in an animal experiment of (potential) pain and/or distress that, within the context of moral justification and scientific endpoints to be met, can be used to avoid or limit pain and/or distress by taking actions such as humane killing or terminating or alleviating the pain and distress. Death as an endpoint should be avoided as far as possible. Another important point to consider is the potential appearance of unexpected outcomes due to the study (e.g. effect of a testing substance), or the creation of new genetically modified strains​<br /> <br /> <br /> == ​B. Guidance &amp; Expectations ==<br /> The following topics must be defined and documented:<br /> * Frequency and personnel involved (animal care and/or research teams) in the study for observation of animals<br /> * Reporting method of issues to veterinarian and Principal Investigator (e.g. phone, email…)<br /> * Implementation of defined humane endpoints, including those more specific to potential study outcomes<br /> * Response in case of unexpected outcomes​<br /> <br /> <br /> &#039;&#039;&#039;​PLEASE DO N​OT FORGET&#039;&#039;&#039;<br /> * To instruct personnel on the potential experimental outcomes impacting animal well-being<br /> * To maintain an effective communication channel with the veterinarian and animal care personnel<br /> * To define as best as possible the humane endpoints for each study, and make them available to all personnel involved​<br /> <br /> <br /> == C. Resources ==<br /> Template to describe information related to animal care and use (all items covered by Section 3.4.1) - 3.4.1 Animal care and use.docx​<br /> <br /> ARRIVE guidelines 2019 for reporting animal research - [[ARRIVE 2.0]]​​<br /> <br /> Online and other available guidance:<br /> * Recognition and Alleviation of Pain in Laboratory Animals, NRC 2009. [https://www.nap.edu/read/12526/chapter/1]<br /> * Humane endpoints, NC3Rs [https://www.nc3rs.org.uk/humane-endpoints]<br /> * Humane endpoints, CCAC [https://3rs.ccac.ca/en/care-and-techniques/pain-management/ct-humane-endpoints.html]<br /> * Human endpoints, overview [https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/humane-endpoints]<br /> * Grimace scales [https://www.nc3rs.org.uk/grimacescales]<br /> * ​Chapters 2, 3, 4 of the Guide for the Care and Use of Laboratory Animals, NRC 2011. [https://www.aaalac.org/resources/theguide.cfm]<br /> * The Reporting of Clinical Signs in Laboratory Animals: FELASA Working Group Report [https://pubmed.ncbi.nlm.nih.gov/25957286/]<br /> <br /> <br /> ----<br /> <br /> back to [[Toolbox]]<br /> <br /> Next item: [[3.4.1.8 Animal health and genetic monitoring]]​​</div>

Bjoerngerlach